The devastating opioid epidemic in the U.S. is a crisis that was created, in part, by healthcare itself as prescriptions for pain-relieving medications rapidly increased in the 2000s. Now, healthcare is at the forefront in trying to fix the problem. At Geisinger, a healthcare system serving more than 1.5 million patients in Pennsylvania and New Jersey, where we work, we are taking a multifaceted approach and seeing a big impact.  By combining data-driven assessments, targeted engagement of high prescribers, EHR-based interventions, and pharmacist support in care management, Geisinger has dramatically reduced opioid prescribing.  In addition, programs promoting safe medication disposal in the surrounding communities reduced the number of left-over opioids in medicine cabinets, helping to stem opioid abuse in the surrounding communities.